Breast Cancer - Hormone Replacement Therapy

Hormone Therapy Doubles Risk of Breast Cancer
A recent study by scientists at Fred Hutchinson Cancer Research Center found a 2.6-fold higher incidence of lobular breast cancer in women who took the estrogen and progestin hormone therapy combination. The study focused on 537 women aged 50 or older who had breast cancer and 492 who did not.

Currently, approximately 8.6 million U.S. women take the combination treatment, and 12 million take estrogen alone. Lobular cancer occurs in the milk-producing lobules. It accounts for 10 percent of breast cancer cases and is on the rise, having increased 35 percent between 1988 and 1995.

Li CI, Weiss NS, Stanford JL, Daling JR. Hormone replacement therapy in relation to risk of lobular and ductal breast carcinoma in middle-aged women. Cancer. 2000;88:2570-7.

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