Breast Cancer - Hormone Replacement Therapy

HRT Update
A new study presented more evidence that hormone replacement therapy (HRT) is linked to breast cancer. The good news is that stopping HRT can bring risk back down.

More than one million British women aged 50 to 64 provided information about their use of HRT and were tracked by researchers for cancer incidence and mortality. Breast cancer risk was substantially greater for women using estrogen-progestin combination drugs, and their risk rose with each additional year of HRT usage. Researchers estimate that use of HRT over the past decade has resulted in 20,000 extra breast cancer cases in the U.K., the majority associated with estrogen-progestin compounds. But five years after cessation, risk came back down.

Million Women Study Collaborators. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet. 2003; 362:419-27.

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